By Terry F. Davies
In A Case-Based Guide to Clinical Endocrinology, Second variation, a popular crew of unusual clinicians once back offers stimulating instruction and insights into a wide selection of endocrine topics, teaching readers modern administration of the stipulations defined and offering distinct access into the literature. Importantly, a number of the vital components within the present curriculum for scientific endocrine education as suggested via the organization of software administrators in scientific Endocrinology, Diabetes and Metabolism are coated during this textual content. completely up-to-date, this re-creation not just covers new remedy techniques but additionally emphasizes the most recent investigative advances in either imaging and molecular diagnostics. to augment studying and retention of information, a question-based method is utilized in a few of the case reviews. scholars, citizens, fellows, and practitioners will locate this connection with be a good approach to evaluate their understanding and bring up their skills and abilities in sufferer research and administration. a useful contribution to the sphere, A Case-Based Guide to Clinical Endocrinology, Second Edition, bargains an analogous comprehensive volume of thought-provoking case-studies that made the 1st version of vital significance to all clinicians who deal with sufferers with endocrine disorders.
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Extra resources for A Case-Based Guide to Clinical Endocrinology
2008;93:2454–62. 2. Colao A, Petersenn S, Newell-Price J, Findling JW, Gu F, Maldonado M, et al. A 12-month phase 3 study of pasireotide in Cushing’s disease. N Engl J Med. 2012;366:914–24. 3. Cooper O, Melmed S. Subclinical hyperfunctioning pituitary adenomas: the silent tumors. Best Pract Res Clin Endocrinol Metab. 2012;26:447–60. 4. Fleseriu M. Medical management of persistent and recurrent cushing disease. Neurosurg Clin N Am. 2012;23:653–68. 5. Fleseriu M. The role of combination medical therapy in acromegaly: hope for the nonresponsive patient.
The pathology report described cytokeratin staining as occurring in round perinuclear structures called fibrous bodies and as such his tumor was classified as a sparsely granulated somatotroph adenoma (Fig. 2). Fig. 2 Immunostaining for tumor cell types (magnification ×400). Sparsely granulated adenoma: cytokeratin immunostaining highlights fibrous bodies, a histological “dot–like” appearance, typically seen in these sparsely granulated tumors (cytokeratin-IHC stain) 2 Acromegaly, Awareness Is Paramount for Early Diagnosis… 21 In experienced hands, surgical remission from acromegaly can be achieved in 70–80 % of cases with microadenomas and <50 % of patients with macroadenomas at presentation.
Confirmation of a diagnosis after an initial failed TSS is paramount. While we considered petrosal sinus sampling to confirm CD as opposed to ectopic ACTH production, repeated assessment of her outside surgical pathology by our pathologist established the presence of a corticotroph adenoma at the first surgery. Persistent Cushing’s Disease The consequences of persistent hypercortisolism are severe and include immunosuppression, poor wound healing, diabetes, high blood pressure, cardiac insufficiency, severe osteoporosis, and increased mortality.
A Case-Based Guide to Clinical Endocrinology by Terry F. Davies